Integrating DNA nanostructures with DNAzymes for biosensing, bioimaging and cancer therapy

Y Liu, P Zhu, J Huang, H He, C Ma, K Wang - Coordination Chemistry …, 2022 - Elsevier
As a natural biomolecule, DNA shows excellent bio-friendliness, programmability and
modifiability, and is an attractive building block for constructing nanostructures. In parallel …

Extension characteristics of TdT and its application in biosensors

H Yang, L Zhu, X Wang, Y Song, Y Dong… - Critical Reviews in …, 2024 - Taylor & Francis
The advantages of rapid amplification of nucleic acid without a template based on terminal
deoxyribonucleotidyl transferase (TdT) have been widely used in the field of biosensors …

A nanozyme-based cascade colorimetric aptasensor for amplified detection of ochratoxin A

F Tian, J Zhou, B Jiao, Y He - Nanoscale, 2019 - pubs.rsc.org
Colorimetric assays have been widely developed for the detection of toxin ochratoxin A
(OTA), but most of them suffer from moderate sensitivity when they are adopted for the …

Dual-recognition aptazyme-driven DNA nanomachine for two-in-one electrochemical detection of pesticides and heavy metal ions

W Wang, Y Xu, N Cheng, Y Xie, K Huang… - Sensors and Actuators B …, 2020 - Elsevier
Bi-detection of chemical risks in different kinds exhibited an increasing significance for food
security considering their general concurrence and synergetic toxicity. In this study, a simple …

Single-molecule lipopolysaccharides identification and the interplay with biomolecules via nanopore readout

R Zhu, F Qin, X Zheng, S Fang, J Ding, D Wang… - Biosensors and …, 2023 - Elsevier
Lipopolysaccharides (LPS) are the major constituent on the cell envelope of all gram-
negative bacteria. They are ubiquitous in air, and are toxic inflammatory stimulators for …

An electrochemical sensor for bacterial lipopolysaccharide detection based on dual functional Cu2+-modified metal–organic framework nanoparticles

Z Li, G Dai, F Luo, Y Lu, J Zhang, Z Chu, P He… - Microchimica Acta, 2020 - Springer
An electrochemical sensor based on dual functional Cu 2+-modified metal–organic
framework nanoparticles (Cu 2+-NMOFs) for sensitive detection of bacterial …

A Massively Parallel In Vivo Assay of TdT Mutants Yields Variants with Altered Nucleotide Insertion Biases

CK Carlson, TB Loveless, M Milisavljevic… - ACS synthetic …, 2024 - ACS Publications
Terminal deoxynucleotidyl transferase (TdT) is a unique DNA polymerase capable of
template-independent extension of DNA. TdT's de novo DNA synthesis ability has found …

Terminal deoxynucleotidyl transferase associated with split G-quadruplex/hemin deoxyribozyme amplification detection for various contaminants in milk based on …

ZT Zhong, YF He, YJ Tang, G Ashraf, H Yang… - Biosensors and …, 2022 - Elsevier
Contaminant residue analysis in milk can provide essential assistance for safety quality and
contamination level management of milk production, which is critical for safeguarding public …

Multiple functionalities of functional nucleic acids for developing high-performance lateral flow assays

J Wang, L Zhu, T Li, X Li, K Huang, W Xu - TrAC Trends in Analytical …, 2022 - Elsevier
Functional nucleic acids (FNAs) have emerged as superior molecular recognition elements
with high binding affinity, specificity, and catalytic activity. Due to multiple functionalities like …

A colorimetric zinc (II) assay based on the use of hairpin DNAzyme recycling and a hemin/G-quadruplex lighted DNA nanoladder

L Zhu, G Li, X Shao, K Huang, Y Luo, W Xu - Microchimica Acta, 2020 - Springer
A method is described for sensitive colorimetric determination of zinc (II) ions that uses (a) a
Zn (II)-responsive hairpin DNAzyme that assists target recycling,(b) hybridization chain …