Genetic, environmental, and aging-related insults can promote the misfolding and
subsequent aggregation of secreted proteins implicated in the pathogenesis of numerous …

The protein homeostasis (proteostasis) system encompasses the cellular processes that
regulate protein synthesis, folding, concentration, trafficking and degradation. In the case of …

Proteostasis, the balance of protein synthesis, folding and degradation, is essential to
maintain cellular function and viability, and the many known intracellular chaperones are …

Clusterin is a glycoprotein present at high concentrations in many extracellular fluids,
including semen. Its increased expression accompanies disorders associated with …

The development of a cure for Alzheimer's disease (AD) has been hindered by complicated
pathologies in brain microenvironment, including β-amyloid protein (Aβ) deposition, metal …

Protein quality control involves many processes that jointly act to regulate the expression,
localization, turnover, and degradation of proteins, and has been highlighted in recent …

Proteostasis refers to a delicately tuned balance between the processes of protein synthesis,
folding, localization, and the degradation of proteins found inside and outside cells. Our …

Several proteins associated with neurodegenerative diseases, such as the mammalian
prion protein (PrP), undergo liquid–liquid phase separation (LLPS), which led to the …

Alzheimer's disease (AD) is primarily driven by the formation of toxic amyloid-β (Aβ)
aggregates, with Aβ42 being a pivotal contributor to disease pathology. This study …

Several proteins associated with neurodegenerative diseases, such as the mammalian
prion protein (PrP), undergo liquid–liquid phase separation (LLPS), which led to the …