Although the incidences are increasing day after day, scientists and researchers taken
individually or by research group are trying to fight against cancer by several ways and also …

The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR)
pathway is one of the key signaling pathways induced by various receptor-tyrosine kinases …

Natural products, an infinite treasure of bioactive scaffolds, have provided an excellent
reservoir for the discovery of drugs since millennium. These naturally occurring, biologically …

Combined chemotherapy and targeted therapy holds immense potential in the management
of advanced gastric cancer (GC). GC tissues exhibit an elevated expression level of protein …

Background Sesquiterpene lactones having α-methylene-γ-lactone moiety are promising
natural metabolites showing various biological activity. One of the major metabolites isolated …

Isoalantolactone (IALT) is one of the isomeric sesquiterpene lactones isolated from the roots
of Inula helenium L. IALT is known to possess various biological and pharmacological …

Nature always remains an inexhaustible source of treasures for mankind. It remains a
mystery for every challenge until the completion of the challenge. While we talk about the …

Apoptosis is a programmed cell death comprising two signaling cascades including the
intrinsic and extrinsic pathways. This process has been shown to be involved in the therapy …

Isoalantolactone possessed various biological activities. However, whether it could treat
breast cancer and its underlying mechanism remained largely unknown. This study was …

Isoalantolactone (ISO), a sesquiterpene lactone isolated from Inula helenium, is known to
have anti-inflammatory activity. Here, using a mouse model of acute lung injury, we …