The discovery of the Klotho (KL) gene, which was originally identified as a putative aging-
suppressor gene, has generated tremendous interest and has advanced understanding of …

A wealth of observational studies show that low testosterone is associated with insulin
resistance and with an increased risk of diabetes and the metabolic syndrome. Experimental …

Cardiac inflammation and oxidative stress play a key role in the pathogenesis of diabetic
cardiomyopathy (DCM). The anti-aging protein Klotho has been found to protect cells from …

More than 300 million years ago, vertebrates emerged from the vast oceans to conquer
gravity and the dry land. With this transition, new adaptations occurred that included …

Abstract αKlotho (Klotho), a type I transmembrane protein and a coreceptor for Fibroblast
Growth Factor-23, was initially thought to be expressed only in a limited number of tissues …

Background and aim Klotho was first identified as a gene associated with aging and
longevity in 1997. α-Klotho is an anti-aging protein and its role in energy metabolism …

A disproportionate expansion of white adipose tissue and abnormal recruitment of
adipogenic precursor cells can not only lead to obesity but also impair glucose metabolism …

The klotho gene is a classical “aging suppressor” gene. Its roles in the pathology of chronic
kidney diseases have been well documented. However, the role of Klotho in tumorigenesis …

Abstract Background: Cardiovascular diseases (CVDs) are the leading cause of morbidity
and mortality in advanced CKD. The major pathological changes of CKD-associated CVD …

Background Klotho proteins (α-and β) are membrane-based circulating proteins that
regulate cell metabolism, as well as the lifespan modulating activity of Fibroblast Growth …