Methadone is one of the most popular synthetic opioids in the world with some favorable
properties making it useful both in the treatment of moderate to severe pain and for opioid …

Purpose. The association of methadone with QT interval prolongation and torsades de
pointes (TdP) is reviewed, and recommendations for preventing QT interval prolongation in …

Description: An independent panel developed cardiac safety recommendations for
physicians prescribing methadone. Methods: Expert panel members reviewed and …

This document reports the consensus of an interdisciplinary panel of research and clinical
experts charged with reviewing the use of opioids for chronic noncancer pain (CNCP) and …

Opioids are increasingly used in alleviating pain, including cancer-related pain and
postoperative pain. Unfortunately, the development of tolerance, the resistance of …

In an effort to enhance patient safety in opioid treatment programs, the Substance Abuse
and Mental Health Saervices Administration convened a multi-disciplinary Expert Panel on …

Methadone is increasingly prescribed for chronic pain, yet the associated mortality appears
to be rising disproportionately relative to other opioid analgesics. We review the available …

We reviewed the literature and found 31 adult cases and 1 newborn case of methadone-
associated QTc interval prolongation and/or torsade de pointes (TdP). Parametric statistics …

We aimed to evaluate electrocardiographic (ECG) abnormalities in mortalities due to pure
methadone toxicity in ICU patients since methadone-related mortality may be due to cardiac …

Discussion We present the first documented case of torsades de pointes related to the use of
propoxyphene, an effective pain killer recently withdrawn from the US market because …