Evolving geographic diversity in SARS-CoV2 and in silico analysis of replicating enzyme 3CLpro targeting repurposed drug candidates
N Chitranshi, VK Gupta, R Rajput, A Godinez… - Journal of Translational …, 2020 - Springer
Background Severe acute respiratory syndrome (SARS) has been initiating pandemics
since the beginning of the century. In December 2019, the world was hit again by a …
since the beginning of the century. In December 2019, the world was hit again by a …
Molecular docking, dynamics, and pharmacology studies on bexarotene as an agonist of ligand‐activated transcription factors, retinoid X receptors
Retinoid X receptors (RXRs) belong to the nuclear receptor superfamily, and upon ligand
activation, these receptors control gene transcription via either homodimerization with …
activation, these receptors control gene transcription via either homodimerization with …
Identification of novel cathepsin B inhibitors with implications in Alzheimer's disease: Computational refining and biochemical evaluation
Amyloid precursor protein (APP), upon proteolytic degradation, forms aggregates of amyloid
β (Aβ) and plaques in the brain, which are pathological hallmarks of Alzheimer's disease …
β (Aβ) and plaques in the brain, which are pathological hallmarks of Alzheimer's disease …
BDNF activates mTOR to upregulate NR2B expression in the rostral anterior cingulate cortex required for inflammatory pain-related aversion in rats
Y Zhang, F Ji, G Wang, D He, L Yang, M Zhang - Neurochemical research, 2018 - Springer
The mechanistic target of rapamycin (mTOR) has been demonstrated to mediate pain-
related aversion induced by formalin in the rostral anterior cingulate cortex (rACC) …
related aversion induced by formalin in the rostral anterior cingulate cortex (rACC) …
Unveiling the Therapeutic Potential of Small Molecule of SVAK-12: A Comprehensive In Silico, In Vitro, and In Vivo Studies on its Neuroprotective Effects and …
Introduction Parkinson's disease (PD) is a neurodegenerative disorder associated with a
progressive loss of dopaminergic cells and as of now, there is no established definitive …
progressive loss of dopaminergic cells and as of now, there is no established definitive …
Computational refinement identifies functional destructive single nucleotide polymorphisms associated with human retinoid X receptor gene
Alterations in the nuclear retinoid X receptor (RXRs) signalling have been implicated in
neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, stroke …
neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, stroke …
Vitamin D3 Exerts a Neuroprotective Effect in Metabolic Syndrome Rats: Role of BDNF/TRKB/Akt/GS3Kβ Pathway
N Aladdin, SA Ghareib - Journal of Biochemical and Molecular …, 2024 - Wiley Online Library
Metabolic syndrome (MetS) is usually associated with cognitive impairment, neuropathic
pain, and reduced brain‐derived neurotrophic factor (BDNF) levels. BDNF via tropomyosin …
pain, and reduced brain‐derived neurotrophic factor (BDNF) levels. BDNF via tropomyosin …
Résistances/sensibilisations aux anti-CD20 (rituximab) dans les lymphomes diffus à grandes cellules B (DLBCL)
H Bentayeb - 2016 - theses.hal.science
Les lymphomes diffus à grandes cellules B (DLBCL) sont la forme de lymphomes non–
Hodgkiniens agressifs la plus fréquente chez l'adulte, et sont très hétérogènes à la fois sur …
Hodgkiniens agressifs la plus fréquente chez l'adulte, et sont très hétérogènes à la fois sur …
Understanding the Retinoid-x-receptor biology and manipulating it as a novel strategy to protect the retina
Y Dheer - 2022 - figshare.mq.edu.au
Glaucoma is a degenerative optic neuropathy affecting nearly 80 million individuals by 2020
worldwide. Glaucoma is mainly manifested as alterations of the optic disc with progressive …
worldwide. Glaucoma is mainly manifested as alterations of the optic disc with progressive …