The gut microbiome as a modulator of healthy ageing

TS Ghosh, F Shanahan, PW O'Toole - … Reviews Gastroenterology & …, 2022 - nature.com
The gut microbiome is a contributory factor in ageing-related health loss and in several non-
communicable diseases in all age groups. Some age-linked and disease-linked …

Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies

S Xu, I Ilyas, PJ Little, H Li, D Kamato, X Zheng… - Pharmacological …, 2021 - Elsevier
The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

Recent advances in modulation of cardiovascular diseases by the gut microbiota

SK Masenga, B Hamooya, J Hangoma… - Journal of Human …, 2022 - nature.com
The gut microbiota has recently gained attention due to its association with cardiovascular
health, cancers, gastrointestinal disorders, and non-communicable diseases. One critical …

Benefits and implications of resveratrol supplementation on microbiota modulations: a systematic review of the literature

AD Inchingolo, G Malcangi, AM Inchingolo… - International Journal of …, 2022 - mdpi.com
Resveratrol is a polyphenol that has been shown to possess many applications in different
fields of medicine. This systematic review has drawn attention to the axis between …

Beneficial effect of the short-chain fatty acid propionate on vascular calcification through intestinal microbiota remodelling

J Yan, Y Pan, W Shao, C Wang, R Wang, Y He… - Microbiome, 2022 - Springer
Background Vascular calcification is a major cause of the high morbidity and mortality of
cardiovascular diseases and is closely associated with the intestinal microbiota. Short-chain …

Microbial peer pressure: the role of the gut microbiota in hypertension and its complications

RR Muralitharan, HA Jama, L Xie, A Peh, M Snelson… - …, 2020 - Am Heart Assoc
There is increasing evidence of the influence of the gut microbiota on hypertension and its
complications, such as chronic kidney disease, stroke, heart failure, and myocardial …

The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging

VE Brunt, TJ LaRocca, AE Bazzoni, ZJ Sapinsley… - GeroScience, 2021 - Springer
Aging is associated with declines in cognitive performance, which are mediated in part by
neuroinflammation, characterized by astrocyte activation and higher levels of pro …

Gut microbes in cardiovascular diseases and their potential therapeutic applications

L Jin, X Shi, J Yang, Y Zhao, L Xue, L Xu, J Cai - Protein & cell, 2021 - academic.oup.com
Microbial ecosystem comprises a complex community in which bacteria interact with each
other. The potential roles of the intestinal microbiome play in human health have gained …

Gut microbiota-derived TMAO: a causal factor promoting atherosclerotic cardiovascular disease?

M Canyelles, C Borràs, N Rotllan, M Tondo… - International journal of …, 2023 - mdpi.com
Trimethylamine-N-oxide (TMAO) is the main diet-induced metabolite produced by the gut
microbiota, and it is mainly eliminated through renal excretion. TMAO has been correlated …

Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis

M Witkowski, M Witkowski, J Friebel… - Cardiovascular …, 2022 - academic.oup.com
Aims Gut microbiota and their generated metabolites impact the host vascular phenotype.
The metaorganismal metabolite trimethylamine N-oxide (TMAO) is both associated with …