Although originally discovered as neuronal growth cone-collapsing factors, repulsive
guidance molecules (RGMs) are now known as key players in many fundamental …

LIM-domain proteins are a large family of proteins that are emerging as key molecules in a
wide variety of human cancers. In particular, all members of the human LIM-domain-only …

Direct neuronal reprogramming is a promising approach to regenerate neurons from local
glial cells. However, mechanisms of epigenome remodeling and co-factors facilitating this …

The mammalian nervous system is made up of an extraordinary array of diverse cells that
form intricate functional connections. The programs underlying cell lineage specification …

How multiple epigenetic layers and transcription factors (TFs) interact to facilitate brain
development is largely unknown. Here, to systematically map the regulatory landscape of …

Pro-neural transcription factors and small molecules can induce the reprogramming of
fibroblasts into functional neurons; however, the immediate-early molecular events that …

The establishment of correct neurotransmitter characteristics is an essential step of neuronal
fate specification in CNS development. However, very little is known about how a battery of …

While microRNAs have emerged as an important component of gene regulatory networks, it
remains unclear how microRNAs collaborate with transcription factors in the gene networks …

In vertebrates, primary sex determination refers to the decision within a bipotential organ
precursor to differentiate as a testis or ovary. Bifurcation of organ fate begins between …

Background Children born extremely preterm are at heightened risk for intellectual and
social impairment, including Autism Spectrum Disorder (ASD). There is increasing evidence …