Recent molecular studies have expanded the biological contexts in which topoisomerase II
(TOP2) has crucial functions, including DNA replication, transcription and chromosome …

Purpose To update the recommendations for the use of tumor marker tests in the prevention,
screening, treatment, and surveillance of breast cancer. Methods For the 2007 update, an …

In the past decades, transcriptomic studies have revolutionized cancer treatment and
diagnosis. However, tumor sequencing strategies typically result in loss of spatial …

The year 2007 marks exactly two decades since Human Epidermal Growth Factor Receptor-
2 (HER2) was functionally implicated in the pathogenesis of human breast cancer. This …

Abstract Background: Updated National Academy of Clinical Biochemistry (NACB)
Laboratory Medicine Practice Guidelines for the use of tumor markers in the clinic have been …

The molecular heterogeneity and distinct features of HER2-low breast cancers, particularly
in the Chinese population, are not well understood, limiting its precise management in the …

Topoisomerase poisons are chemotherapeutic agents that are used extensively for treating
human malignancies. These drugs can be highly effective, yet tumors are frequently …

One-third of patients with breast cancer overexpress the ERBB2 receptor tyrosine kinase,
which is associated not only with a more aggressive phenotype but also reduced …

Approximately 8% of breast cancers show increased copy numbers of chromosome 17
centromere (CEP17) by fluorescence in situ hybridization (FISH)(ie average CEP17> 3.0 per …

Background: The present approach to cancer treatment is often referred to as “trial and error”
or “one size fits all.” This practice is inefficient and frequently results in inappropriate therapy …