Cancers are complex ecosystems composed of malignant cells embedded in an intricate
microenvironment made of different non-transformed cell types and extracellular matrix …

The tumor microenvironment is a complex structure composed of the extracellular matrix
(ECM) and nontumoral cells (notably cancer-associated fibroblasts (CAFs) and immune …

Deep learning is usually combined with a single detection technique in the field of disease
diagnosis. This study focused on simultaneously combining deep learning with multiple …

Accurate and rapid diagnosis of breast cancer is particularly important since it becomes the
primary malignant tumor threatening women's health. Although pathological diagnosis with …

Gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), which
serves the critical pillar for the treatment of non-small cell lung cancer (NSCLC). However …

Fibrillar collagens promote cell proliferation, migration, and survival in various epithelial
cancers and are generally associated with tumor aggressiveness. However, the impact of …

Type I collagen is the major adhesive component in breast interstitial stroma, which
represents the first barrier against tumor cell invasion after basement-membrane …

Low density lipoprotein receptor related protein-1 (LRP-1) is a large ubiquitous endocytic
receptor mediating the clearance of various molecules from the extracellular matrix. Several …

Abstract The Discoidin Domain Receptors (DDRs) constitute a unique set of receptor
tyrosine kinases that signal in response to collagen. Using an inducible expression system …

Background: TP53 plays critical roles in sensitivity to chemotherapy, and aging. Collagen is
very important in aging. The molecular structure and biochemical properties of collagen …