Diabetic retinopathy (DR) is a chronic complication of diabetes and a leading cause of
blindness in the industrialized world. Traditional risk factors, such as glycemic control and …

The present study aimed to summarize and validate the genomic association signals for
diabetic retinopathy (DR), proliferative DR, and diabetic macular edema/diabetic …

Aims Individuals with supranormal left ventricular ejection fraction (snLVEF; LVEF> 70%)
have increased mortality. However, the genetic and phenotypic profile of snLVEF remains …

While polygenic risk scores (PRSs) enable early identification of genetic risk for chronic
obstructive pulmonary disease (COPD), predictive performance is limited when the …

Importance Primary open-angle glaucoma (POAG) is a highly heritable disease, with 127
identified risk loci to date. Polygenic risk score (PRS) may provide a clinically useful …

The success of genome-wide association studies (GWASs) in uncovering genetic variants
associated with complex eye diseases has paved the way for the development of risk …

Insulin is amongst the human genome's most well-studied genes/proteins due to its
connection to metabolic health. Within this article, we review literature and data to build a …

Population-based genomic screening may help diagnose individuals with disease-risk
variants. Here, we perform a genome-first evaluation for nine disorders in 29,039 …

Stromal cell-derived factor-1 (SDF-1) and its receptor CXC chemokine 4 (CXCR4) have
been demonstrated to play critical roles in diabetic retinopathy (DR). This study investigated …

Background Diabetic retinopathy (DR) is characterized by ischemia, hypoxia, and
angiogenesis. Erythropoietin (EPO), an angiogenic hormone, is upregulated in DR, and the …