Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments
Ketamine has emerged as a transformative and mechanistically novel pharmacotherapy for
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development
There is an urgent need to improve the pharmacotherapy of schizophrenia despite the
introduction of important new medications. New treatment insights may come from …
introduction of important new medications. New treatment insights may come from …
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption
Period (Per) genes are involved in regulation of the circadian clock and are thought to
modulate several brain functions. We demonstrate that Per2 Brdm1 mutant mice, which have …
modulate several brain functions. We demonstrate that Per2 Brdm1 mutant mice, which have …
Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the …
Adolescence is a developmental period which the risk of drug and alcohol abuse increases.
Since mesolimbic dopaminergic system undergoes developmental changes during …
Since mesolimbic dopaminergic system undergoes developmental changes during …
Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses …
JH Krystal, EB Perry, R Gueorguieva… - Archives of general …, 2005 - jamanetwork.com
Background In healthy individuals, ketamine hydrochloride and amphetamine sulfate
produce cognitive, behavioral, and subjective effects resembling endogenous psychoses …
produce cognitive, behavioral, and subjective effects resembling endogenous psychoses …
Pharmacological treatment of anxiety disorders: Current treatments and future directions
Modern pharmacological treatments for anxiety disorders are safer and more tolerable than
they were 30 years ago. Unfortunately, treatment efficacy and duration have not improved in …
they were 30 years ago. Unfortunately, treatment efficacy and duration have not improved in …
Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis
M Roberto, P Schweitzer, SG Madamba… - Journal of …, 2004 - Soc Neuroscience
The modulation of glutamatergic transmission by ethanol may contribute to ethanol
intoxication, reinforcement, tolerance, and dependence. Therefore, we used in vitro …
intoxication, reinforcement, tolerance, and dependence. Therefore, we used in vitro …
The mechanistic classification of addictive drugs
C Lüscher, MA Ungless - PLoS medicine, 2006 - journals.plos.org
The Mechanistic Classification of Addictive Drugs | PLOS Medicine Skip to main content
Advertisement PLOS Medicine Browse Current Issue Journal Archive Special Issues …
Advertisement PLOS Medicine Browse Current Issue Journal Archive Special Issues …
Glial and glutamatergic markers in depression, alcoholism, and their comorbidity
JJ Miguel-Hidalgo, R Waltzer, AA Whittom… - Journal of affective …, 2010 - Elsevier
BACKGROUND: Alteration of glutamatergic neurotransmission in the prefrontal cortex (PFC)
may contribute to the pathophysiology of alcoholism and major depressive disorder (MDD) …
may contribute to the pathophysiology of alcoholism and major depressive disorder (MDD) …
[HTML][HTML] Communication networks in the brain: neurons, receptors, neurotransmitters, and alcohol
DM Lovinger - Alcohol Research & Health, 2008 - ncbi.nlm.nih.gov
Nerve cells (ie, neurons) communicate via a combination of electrical and chemical signals.
Within the neuron, electrical signals driven by charged particles allow rapid conduction from …
Within the neuron, electrical signals driven by charged particles allow rapid conduction from …