Combination of dissolving microneedles with nanosuspension and co-grinding for transdermal delivery of ketoprofen

D Ramadon, F Ulayya, AS Qur'ani, I Iskandarsyah… - Pharmaceuticals, 2023 - mdpi.com
Ketoprofen is an anti-inflammatory agent that may cause gastric irritation if administered
orally. Dissolving microneedles (DMN) can be a promising strategy to overcome this issue …

How to improve solubility and dissolution of irbesartan by fabricating ternary solid dispersions: optimization and in-vitro characterization

A Akram, M Irfan, WA Abualsunun, DM Bukhary… - Pharmaceutics, 2022 - mdpi.com
The purpose of this study is to improve the solubility and dissolution of a poorly soluble drug,
Irbesartan, using solid dispersion techniques. For that purpose, different polymers such as …

Preparation and characterization of solid dispersion freeze-dried efavirenz–polyvinylpyrrolidone K-30

L Fitriani, A Haqi, E Zaini - Journal of advanced pharmaceutical …, 2016 - journals.lww.com
The aim of this research is to prepare and characterize solid dispersion of efavirenz–
polyvinylpyrrolidone (PVP) K-30 by freeze drying to increase its solubility. Solid dispersion of …

Synthesis and characterization of zinc basic salt–loaded PVA-PEI polymeric composite for antimicrobial activity and triboelectric nanogenerator applications

AT Reda, TG Weldemhret, JY Park, S Lim… - Sensors and Actuators A …, 2024 - Elsevier
There is a growing global demand for biodegradable, economical, and versatile materials.
Accordingly, a novel material called zinc basic salt-loaded polyvinyl alcohol-polyethylene …

Evaluation of proanthocyanidin-crosslinked sericin/alginate blend for ketoprofen extended release

ED de Freitas, BM Lima, PCP Rosa… - Advanced Powder …, 2019 - Elsevier
Sericin and alginate blend has shown good results for obtaining sustained release dosage
forms. In the case of ketoprofen, it was necessary to resort to the use of the proanthocyanidin …

Development of sericin/alginate beads of ketoprofen using experimental design: Formulation and in vitro dissolution evaluation

ED de Freitas, PCP Rosa, MGC da Silva, MGA Vieira - Powder technology, 2018 - Elsevier
The development of new forms of drugs from the current existing active principles is an
alternative to the costly and time-consuming process of developing new ones. The blend of …

[PDF][PDF] Preparation of eutectic mixture of ketoprofen and nicotinamide for enhanced dissolution rate

E Zaini, YS Wahyuni, A Halim… - Int J Pharm Sci Rev …, 2015 - researchgate.net
To enhance the dissolution rate of ketoprofen, a poorly water-soluble drug, eutectic mixture
of ketoprofen with nicotinamide had been prepared by melting technique. The binary phase …

Molecular structure of ketoprofen-polyvinylpyrrolidone solid dispersions prepared by different amorphization methods

SK Wilke, CJ Benmore, V Menon, D Smith… - RSC …, 2024 - pubs.rsc.org
Amorphous solid dispersions (ASDs) are a widely studied formulation approach for
improving the bioavailability of poorly water-soluble pharmaceuticals. Yet, a complete …

[PDF][PDF] Preparation and characterization of quercetin-polyvinylpyrrolidone K-30 spray dried solid dispersion

PI Febriyenti, E Zaini, F Ismed… - Journal of Pharmacy & …, 2020 - academia.edu
Abstract Resumen Context: The use of quercetin as a potential active pharmaceutical
ingredient is limited by low aqueous solubility leading to low bioavailability. A spray-dried …

An empirical predictive model for determining the aqueous solubility of BCS class IV drugs in amorphous solid dispersions

S Raparla, C Lampa, X Li, BR Jasti - Drug Development and …, 2024 - Taylor & Francis
Context Determining solubility of drugs is laborious and time-consuming process that may
not yield meaningful results. Amorphous solid dispersion (ASD) is a widely used solubility …