X-ray free-electron lasers provide femtosecond-duration pulses of hard X-rays with a peak
brightness approximately one billion times greater than is available at synchrotron radiation …

Self‐assembly of nanoparticles (NPs) has evolved into a powerful tool for the synthesis of
superstructures with tailored properties. The quality, diversity, and complexity of synthesized …

The emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by
superconducting accelerator technology enables the measurement of significantly more …

The number of noisy images required for molecular reconstruction in single-particle
cryoelectron microscopy (cryo-EM) is governed by the autocorrelations of the observed …

The analysis of a single-particle imaging (SPI) experiment performed at the AMO beamline
at LCLS as part of the SPI initiative is presented here. A workflow for the three-dimensional …

The possibility of imaging single proteins constitutes an exciting challenge for x-ray lasers.
Despite encouraging results on large particles, imaging small particles has proven to be …

X-ray free electron lasers (XFELs) now routinely produce millijoule level pulses of x-ray
photons with tens of femtoseconds duration. Such x-ray intensities gave rise to the idea that …

Diffraction before destruction using X-ray free-electron lasers (XFELs) has the potential to
determine radiation-damage-free structures without the need for crystallization. This article …

The field of structural DNA nanotechnology has evolved remarkably—from the creation of
artificial immobile junctions to the recent DNA–protein hybrid nanoscale shapes—in a span …

Imaging of proteins at the single-molecule level can reveal conformational variability, which
is essential for the understanding of biomolecules. To this end, a biologically relevant state …