Since the beginning of the industrial age, material performance and design have been in the
midst of innovation of many disruptive technologies. Today's electronics, space, medical …

Composite materials and structures are inherently inhomogeneous and anisotropic across
multiple scales. Multiscale modelling offers opportunities to understand the coupling of …

This article focuses on computational multiscale methods for the mechanical response of
nonlinear heterogeneous materials. After a short historical note, a brief overview is given of …

The development of a predictive model for bone remodeling is becoming increasingly
important for medical applications such as bone surgery or bone substitutes like prostheses …

This paper presents a finite element method (FEM)-based fracture risk assessment in patient-
specific osteoporotic lumbar vertebra L1. The influence of osteoporosis is defined by …

The macroscopic behavior of complex heterogeneous materials is governed by the
interactions between their constituents at the microstructural scale. This has fostered a large …

We propose a procedure to approximate the large elastic deformations of a fiber reinforced
layer by a two-scale decoupled homogenization numerical procedure. The nonlinear micro …

We propose a novel two-scale (meso-macro-scale) approach to computationally capture
cancellous bone remodelling allowing for efficient and effective numerical implementation …

An evaluation of the impact of osteoporosis on loss of spinal stability, with or without
intervertebral disc degeneration, using computational analysis is presented. The research …

Numerical prediction of osteoporosis evolution is a challenging objective in medicine,
particularly when one desires to account for patient dependency. The use of statistical …