The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

The abilities to sense environmental and internal temperatures are required for survival,
both for maintenance of homeostasis and for avoidance of tissue-damaging noxious …

Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …

Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …

We feel a wide range of temperatures spanning from cold to heat. Within this range,
temperatures over about 43° C and below about 15° C evoke not only a thermal sensation …

Living organisms must evaluate changes in environmental and internal temperatures to
mount appropriate physiological and behavioral responses conducive to survival. Classical …

The newly discovered endocannabinoid system (ECS; comprising the endogenous lipid
mediators endocannabinoids present in virtually all tissues, their G-protein-coupled …

The vanilloid receptor subtype 1 (VR1)/(TRPV1), binding capsaicin, is a non‐selective cation
channel that recently has been shown in human keratinocytes in vitro and in vivo. However …

Regular keratinocyte differentiation is crucial for the formation of an intact epidermal barrier
and is triggered by extracellular calcium. Disturbances of epidermal barrier formation and …