Protein ADP-ribosylation is essential for the regulation of several cellular pathways,
enabling dynamic responses to diverse pathophysiological conditions. It is modulated …

Age and DNA repair deficiencies are strong risk factors for developing cancer. This is
reflected in the comorbidity of cancer with premature aging diseases associated with DNA …

Telomeres protect the ends of chromosomes but shorten following cell division in the
absence of telomerase activity. When telomeres become critically short or damaged, a DNA …

RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and
animals. These helicases play important roles in multiple cellular functions, including DNA …

A rare and autosomal recessive premature aging disorder, Werner syndrome (WS) is
characterized by the early onset of aging-associated diseases, including shortening stature …

Genetic predisposition accounts for nearly 10% of all melanoma cases and has been
associated with a dozen moderate-to high-penetrance genes, including CDKN2A, CDK4 …

Efficient mechanisms for genomic maintenance (ie, DNA repair and DNA replication) are
crucial for cell survival. Aging and obesity can lead to the dysregulation of genomic …

Research question How do age and normo-or oligoasthenozoospermia affect telomere
length dynamics in spermatozoa and blood? Design Sperm and blood samples were …

Helicases are molecular motors that play central roles in nucleic acid metabolism. Mutations
in genes encoding DNA helicases of the RecQ and iron–sulfur (Fe–S) helicase families are …

Oxidative damage to telomeres leads to telomere attrition and genomic instability, resulting
in poor cell viability. Telomere dynamics contribute to the maintenance of telomere integrity; …