Cisplatin is one of the most widely used chemotherapeutic agents for various solid tumors in
the clinic due to its high efficacy and broad spectrum. The antineoplastic activity of cisplatin …

Ethnopharmacological relevance Chemotherapy is a common cancer treatment strategy.
However, its effectiveness is constrained by toxicity and adverse effects. The Lamiaceae …

Cisplatin is a highly effective antineoplastic agent used to treat solid tumors. Unfortunately,
the administration of this drug leads to significant side effects, including ototoxicity …

The incidence of liver diseases such as hepatitis, fibrosis, cirrhosis, and liver cancer is one
of the world's most significant health challenges. Liver diseases can be caused by a variety …

Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular
cisplatin (cis-diammine dichloroplatinum II). To our knowledge, no systematic review has …

Aminoglycosides and the anticancer drug cisplatin can cause permanent hearing loss,
which impacts patients' quality of life and results in considerable subsequent costs. Since …

Objectives Cisplatin-induced ototoxicity is a common permanent consequence of curative
chemoradiation for locally advanced head and neck squamous cell carcinoma (HNSCC) …

Purpose: To evaluate the effect of hyperin in cisplatin-induced liver injury in mice. Methods:
Mice were pretreated with hyperin at doses of 25 mg/kg and 50 mg/kg, respectively, for six …

Cisplatin is a highly effective chemotherapeutic. Unfortunately, its use is limited by cisplatin‐
induced ototoxicity (CIO). Substantial research has been performed to uncover the genetic …

The need for monitoring hearing and auditory function during drug therapy and other
treatments that have the potential to cause hearing loss is well documented. Besides the …