Type 1 diabetes: pathogenesis and prevention

KM Gillespie - Cmaj, 2006 - Can Med Assoc
Type 1 diabetes results from the autoimmune destruction of insulin-producing β cells in the
pancreas. Genetic and, as yet undefined, environmental factors act together to precipitate …

Autoimmune destruction of pancreatic β cells

JW Yoon, HS Jun - American journal of therapeutics, 2005 - journals.lww.com
Type 1 diabetes results from the destruction of insulin-producing pancreatic β cells by a β
cell-specific autoimmune process. β Cell autoantigens, macrophages, dendritic cells, B …

Autoantibodies as predictors of disease

D Leslie, P Lipsky, AL Notkins - The Journal of clinical …, 2001 - Am Soc Clin Investig
Specificity of prediction with an autoantibody marker reflects the chance that a person
without that marker will remain disease-free. It is calculated by dividing the number of …

Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The Childhood Diabetes in Finland Study Group.

P Kulmala, K Savola, JS Petersen… - The Journal of …, 1998 - Am Soc Clin Investig
An unselected population of 755 siblings of children with insulin-dependent diabetes
mellitus (IDDM) was studied to evaluate the predictive characteristics of islet cell antibodies …

[PDF][PDF] Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes

RDG Leslie, MA Atkinson, AL Notkins - Diabetologia, 1999 - researchgate.net
Type I (insulin-dependent) diabetes mellitus results from destruction of the beta cells of the
islets of Langerhans, usually leading to absolute insulin deficiency. Although some patients …

IA-2 antibodies–a sensitive marker of IDDM with clinical onset in childhood and adolescence

K Savola, E Bonifacio, E Sabbah, P Kulmala… - Diabetologia, 1998 - Springer
To study the relationship of IA-2 antibodies (IA-2A) to other autoantibodies and genetic risk
markers in insulin-dependent diabetes mellitus (IDDM), 758 children and adolescents …

Comparative aspects of diabetes mellitus in dogs and cats

M Hoenig - Molecular and cellular endocrinology, 2002 - Elsevier
Diabetes mellitus is a common disease in cats and dogs. Its incidence is increasing,
possibly due to an increase in obesity in both species. Different types of diabetes have been …

Immunology in diabetes: an update

DB Schranz, Å Lernmark - Diabetes/metabolism reviews, 1998 - Wiley Online Library
Abstract Type 1 (insulin‐dependent) diabetes mellitus is strongly associated with
autoimmune phenomena connected to the loss of β‐cells in the pancreatic islets. Despite …

Pancreatic biopsy as a procedure for detecting in situ autoimmune phenomena in type 1 diabetes: close correlation between serological markers and histological …

A Imagawa, T Hanafusa, S Tamura, M Moriwaki… - Diabetes, 2001 - Am Diabetes Assoc
To better understand the pathogenesis of type 1 diabetes, we have developed pancreatic
biopsy under laparoscope for recent-onset type 1 diabetic patients. The patients included 29 …

Beta-cell, thyroid, gastric, adrenal and coeliac autoimmunity and HLA-DQ types in type 1 diabetes

CEM De Block, IH De Leeuw… - Clinical & …, 2001 - academic.oup.com
The autoimmune attack in type 1 diabetes is not only targeted to β cells. We assessed the
prevalence of thyroid peroxidase (aTPO), parietal cell (PCA), antiadrenal (AAA) and …