Norovirus, an RNA virus of the family Caliciviridae, is a human enteric pathogen that causes
substantial morbidity across both health care and community settings. Several factors …

Noroviruses are small, positive-sense RNA viruses within the family Caliciviridae, and are
now accepted widely as a major cause of acute gastroenteritis in both developed and …

Intestinal microbial communities have profound effects on host physiology. Whereas the
symbiotic contribution of commensal bacteria is well established, the role of eukaryotic …

The cell tropism of human noroviruses and the development of an in vitro infection model
remain elusive. Although susceptibility to individual human norovirus strains correlates with …

It is unclear why disease occurs in only a small proportion of persons carrying common risk
alleles of disease susceptibility genes. Here we demonstrate that an interaction between a …

Human noroviruses (HuNoVs) are a leading cause of foodborne disease and severe
childhood diarrhea, and they cause a majority of the gastroenteritis outbreaks worldwide …

The intestinal microbiota exerts a marked influence in the mammalian host, both during
homeostasis and disease. However, until very recently, there has been relatively little focus …

Among animals used in research, teaching and testing, mice are now widely recognized as
the most important model for human diseases and disorders. They comprise the majority of …

Host resistance to viral infection requires type I (α/β) and II (γ) interferon (IFN) production.
Another important defense mechanism is the degradative activity of macroautophagy (herein …

Human noroviruses are a major cause of epidemic and sporadic gastroenteritis worldwide
and can chronically infect immunocompromised patients. Efforts to develop effective …