The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes
Observed in PRL Receptor Knockout Mice | Endocrine Reviews | Oxford Academic Skip to Main …

▪ Abstract Cytokines and interferons are molecules that play central roles in the regulation of
a wide array of cellular functions in the lympho-hematopoietic system. These factors …

Investigation into the mechanism of cytokine signaling led to the discovery of the JAK/STAT
pathway. Following the binding of cytokines to their cognate receptor, signal transducers …

The early colocalization of T cells and the potent immunostimulatory cytokine IFN-gamma to
atherosclerotic lesions suggest that the immune system contributes to atherogenesis. Since …

The signal transducer and activator of transcription, STAT5b, has been implicated in signal
transduction pathways for a number of cytokines and growth factors, including growth …

Cytoplasmic Janus protein tyrosine kinases (JAKs) are crucial components of diverse signal
transduction pathways that govern cellular survival, proliferation, differentiation and …

The Signal Transducer and Activator of Transcription (STAT) family of proteins was first
discovered in the 1990's as key proteins in cytokine signaling. Since then, the field has …

Gamma interferon activation site (GAS) elements are short stretches of DNA, originally
defined as a requirement for the rapid transcriptional induction of genes in response to …

Severe combined immunodeficiency disease (SCID) refers to a spectrum of inherited
immunodeficiencies that together represent the most severe forms of primary …