Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities

KD Davis, N Aghaeepour, AH Ahn, MS Angst… - Nature Reviews …, 2020 - nature.com
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …

Corneal nerves in health and disease

MA Al-Aqaba, VK Dhillon, I Mohammed… - Progress in retinal and …, 2019 - Elsevier
The cornea is the most sensitive structure in the human body. Corneal nerves adapt to
maintain transparency and contribute to corneal health by mediating tear secretion and …

Diagnostic criteria for small fibre neuropathy in clinical practice and research

G Devigili, S Rinaldo, R Lombardi, D Cazzato… - Brain, 2019 - academic.oup.com
The diagnostic criteria for small fibre neuropathy are not established, influencing the
approach to patients in clinical practice, their access to disease-modifying and symptomatic …

Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation

M Wu, LJ Hill, LE Downie, HR Chinnery - Progress in Retinal and Eye …, 2022 - Elsevier
In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with
their important roles in the maintenance of nerves in both homeostasis and inflammation …

Gold standard for diagnosis of DPN

Y Yu - Frontiers in endocrinology, 2021 - frontiersin.org
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus. It often
causes symmetrical paresthesia, loss of sensation, and hyperalgesia. Without early …

Painful diabetic peripheral neuropathy: practical guidance and challenges for clinical management

FG Preston, DR Riley, S Azmi… - … , Metabolic Syndrome and …, 2023 - Taylor & Francis
Painful diabetic peripheral neuropathy (PDPN) is present in nearly a quarter of people with
diabetes. It is estimated to affect over 100 million people worldwide. PDPN is associated …

Small fiber neuropathy in the cornea of Covid-19 patients associated with the generation of ocular surface disease

A Barros, J Queiruga-Piñeiro, J Lozano-Sanroma… - The Ocular Surface, 2022 - Elsevier
Purpose To describe the association between Sars-CoV-2 infection and small fiber
neuropathy in the cornea identified by in vivo corneal confocal microscopy. Methods Twenty …

[HTML][HTML] Corneal confocal microscopy: a biomarker for diabetic peripheral neuropathy

IN Petropoulos, G Ponirakis, M Ferdousi, S Azmi… - Clinical …, 2021 - Elsevier
Purpose Diagnosing early diabetic peripheral neuropathy remains a challenge due to
deficiencies in currently advocated end points. The cornea is densely innervated with small …

[HTML][HTML] Review of techniques useful for the assessment of sensory small fiber neuropathies: report from an IFCN expert group

RJ Verdugo, JM Matamala, K Inui, R Kakigi… - Clinical …, 2022 - Elsevier
Nerve conduction studies (NCS) are an essential aspect of the assessment of patients with
peripheral neuropathies. However, conventional NCS do not reflect activation of small …

[HTML][HTML] Widespread sensory neuropathy in diabetic patients hospitalized with severe COVID-19 infection

A Odriozola, L Ortega, L Martinez, S Odriozola… - diabetes research and …, 2021 - Elsevier
Aims To characterize the distribution and severity of sensory neuropathy using a portable
quantitative sensory testing (QST) device in diabetic patients (DM) hospitalized with severe …