SIR produces its Standards of Practice documents by using the following process. Topics of
relevance and timeliness are conceptualized by the Standards of Practice Committee …

Leukodystrophies are a broad class of genetic disorders that result in disruption or
destruction of central myelination. Although the mechanisms underlying these disorders are …

Background and Objectives To investigate the efficacy and safety of repeated injections of
incobotulinumtoxinA (incoBoNT/A) for treatment of chronic sialorrhea (drooling) associated …

Background: We aimed to review and analyse the effectiveness and safety of botulinum
toxin type A (BoNT-A) injections for drooling in children with cerebral palsy. Data sources …

This paper addresses how to perform an ultrasound assessment of the salivary and lacrimal
glands, how to identify pathological changes, and how to score disease activity, focusing on …

Objective: Botulinum toxin A is known to be effective and safe in managing sialorrhea in
pediatric patients; however, there is no consensus on a protocol for optimal injection sites …

Multiple sulfatase deficiency (MSD) is an ultra-rare neurodegenerative disorder that results
in defective sulfatase post-translational modification. Sulfatases in the body are activated by …

Paediatric anterior drooling has a major impact on the daily lives of children and caregivers.
Intraglandular botulinum neurotoxin type-A (BoNT-A) injections are considered an effective …

Background and purpose Drooling is a challenging entity to manage. Botulinum toxin A
(BOTOX-A) infiltration of salivary glands is a promising alternative to surgical treatment. This …

Botulinum toxin has been used in medicine for the past 30 years. However, there continues
to be controversy about the appropriate uses and dosing, especially in the pediatric …