Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …

Microglia, the immunocompetent cells of the central nervous system (CNS), act as
neuropathology sensors and are neuroprotective under physiological conditions. Microglia …

A diagnosis of motor Parkinson's disease (PD) is preceded by a prolonged premotor phase
with accumulating neuronal damage. Here we examined the temporal relation between α …

Parkinson disease is the second-most common neurodegenerative disorder that affects 2–
3% of the population≥ 65 years of age. Neuronal loss in the substantia nigra, which causes …

Background Cell-to-cell propagation of α-synuclein (α-syn) aggregates is thought to
contribute to the pathogenesis of Parkinson's disease (PD) and underlie the spread of α-syn …

Starting two decades ago with the discoveries of genetic links between alpha-synuclein and
Parkinson's disease risk and the identification of aggregated alpha-synuclein as the main …

Aggregation of α-synuclein (α-syn) is neuropathologically and genetically linked to
Parkinson's disease (PD). Since stereotypic cell-to-cell spreading of α-syn pathology is …

Parkinson's disease (PD) is the second most common neurodegenerative disease,
manifesting as a characteristic movement disorder with a number of additional non-motor …

Most neurodegenerative diseases are characterized by the accumulation of protein
aggregates, some of which are toxic to cells. Mounting evidence demonstrates that in …

In this Perspectives article, Espay and colleagues argue that that the adoption of precision
medicine in Parkinson disease will require a revision of biomarker development efforts, with …