Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

Focal adhesion kinase (FAK) is a scaffold and tyrosine kinase protein that binds to itself and
cellular partners through its four-point-one, ezrin, radixin, moesin (FERM) domain. Recent …

Focal adhesions undergo myosin-II-mediated maturation wherein they grow and change
composition to modulate integrin signalling for cell migration, growth and differentiation. To …

Integrin adhesion receptors are essential for the normal function of most multicellular
organisms, and defective integrin activation or integrin signaling is associated with an array …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

Integrins are heterodimeric, transmembrane receptors that are expressed in all cells,
including those in the heart. They participate in multiple critical cellular processes including …

Platelet aggregation is a critical event in thrombus formation and thus has extensive
involvement in physiological and pathological processes. The aggregation response …

The disassembly of integrin-containing focal adhesions (FAs) at mitotic entry is essential for
cell rounding, mitotic retraction fibre formation, bipolar spindle positioning and chromosome …

Increased affinity of integrins for the extracellular matrix (activation) regulates cell adhesion
and migration, extracellular matrix assembly, and mechanotransduction. Major uncertainties …

The formation of tissues and organs requires cells to adhere to each other and/or to migrate
and polarize in contact with components of the extracellular matrix. The connection between …