The microbiome plays an important role in a wide variety of skin disorders. Not only is the
skin microbiome altered, but also surprisingly many skin diseases are accompanied by an …

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Psoriatic arthritis (PsA) is part of a group of closely related clinical phenotypes ('psoriatic
disease') that is defined by shared molecular pathogenesis resulting in excessive …

Metabolic programming controls immune cell lineages and functions, but little is known
about γδ T cell metabolism. Here, we found that γδ T cell subsets making either interferon-γ …

Psoriasis has long been known as a disease with many complications, but was attributed to
diet and obesity. However, in recent years, psoriasis itself has been recognized as a series …

Obesity is a major risk factor for psoriasis, but how obesity disrupts the regulatory
mechanisms that keep skin inflammation in check is unclear. Here, we found that skin was …

Psoriasis is a chronic inflammatory skin disease. Immunological, genetic, and environmental
factors, including diet, play a part in the pathogenesis of psoriasis. Metabolic syndrome or its …

Although it is known that psoriasis is strongly associated with obesity, the mechanistic
connection between diet and skin lesions is not well established. Herein, we showed that …

In obesity, hypertrophic adipocytes secrete high amounts of adipocytokines, resulting in low-
grade inflammation amplified by infiltrating proinflammatory macrophages, oxidative stress …

Patients with psoriasis are frequently complicated with metabolic syndrome; however, it is
not fully understood how obesity and dyslipidemia contribute to the pathogenesis of …