Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms

ER Drury, J Wu, JC Gigliotti, TH Le - Physiological Reviews, 2024 - journals.physiology.org
The teleology of sex differences has been argued since at least as early as Aristotle's
controversial Generation of Animals more than 300 years BC, which reflects the sex bias of …

Salt sensitivity of blood pressure in Black people: the need to sort out ancestry versus epigenetic versus social determinants of its causation

F Elijovich, A Kirabo, CL Laffer - Hypertension, 2024 - Am Heart Assoc
Race is a social construct, but self-identified Black people are known to have higher
prevalence and worse outcomes of hypertension than White people. This may be partly due …

Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations

J Liang, TH Le, DRV Edwards, BO Tayo… - PLoS …, 2017 - journals.plos.org
Hypertension is a leading cause of global disease, mortality, and disability. While individuals
of African descent suffer a disproportionate burden of hypertension and its complications …

Non-coding RNA-associated ceRNA networks in a new contrast-induced acute kidney injury rat model

W Cheng, XW Li, YQ Xiao, SB Duan - Molecular Therapy-Nucleic Acids, 2019 - cell.com
Contrast-induced acute kidney injury (CI-AKI) is a severe complication of intravascular
applied radial contrast media, and recent progress in interventional therapy and …

[HTML][HTML] Sex-specific adaptations to high-salt diet preserve electrolyte homeostasis with distinct sodium transporter profiles

DL Torres-Pinzon, DL Ralph… - … of Physiology-Cell …, 2021 - journals.physiology.org
Kidneys continuously filter an enormous amount of sodium and adapt kidney Na+
reabsorption to match Na+ intake to maintain circulatory volume and electrolyte …

Renal Na-handling defect associated with PER1-dependent nondipping hypertension in male mice

LG Douma, MR Holzworth… - American Journal …, 2018 - journals.physiology.org
Many physiological functions have a circadian rhythm, including blood pressure (BP). BP is
highest during the active phase, whereas during the rest period, BP dips 10–20%. Patients …

VEGF‐C attenuates renal damage in salt‐sensitive hypertension

S Beaini, Y Saliba, J Hajal, V Smayra… - Journal of Cellular …, 2019 - Wiley Online Library
Salt‐sensitive hypertension is a major risk factor for renal impairment leading to chronic
kidney disease. High‐salt diet leads to hypertonic skin interstitial volume retention …

Intrarenal angiotensin-converting enzyme: the old and the new

S Culver, C Li, HM Siragy - Current hypertension reports, 2017 - Springer
Abstract Purpose of Review The intrarenal renin-angiotensin-aldosterone system (RAS) is
an independent paracrine hormonal system with an increasingly prominent role in …

Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19

L Han, X Wei, C Liu, G Volpe, Z Wang, T Pan, Y Yuan… - BioRxiv, 2020 - biorxiv.org
Stopping COVID-19 is a priority worldwide. Understanding which cell types are targeted by
SARS-CoV-2 virus, whether interspecies differences exist, and how variations in cell state …

Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort

PL Chu, JC Gigliotti, S Cechova… - American Journal …, 2023 - journals.physiology.org
Collectrin (Tmem27), an angiotensin-converting enzyme 2 homologue, is a chaperone of
amino acid transporters in the kidney and endothelium. Global collectrin knockout (KO) mice …