Vaccines are one of the most powerful technologies supporting public health. The adaptive
immune response induced by immunization arises following appropriate activation and …

The quest for a prophylactic AIDS vaccine is ongoing, but it is now clear that the successful
vaccine must elicit protective antibody responses. Accordingly, intense efforts are underway …

We compare immunogenicity and protective efficacy of an HIV vaccine comprised of env and
gag DNA and Env (Envelope) proteins by co-administration of the vaccine components in …

Advantages of DNA vaccination against infectious diseases over more classical
immunization methods include the possibilities for rapid manufacture, fast adaptation to …

The naked delivery of nucleic acid vaccines is notoriously inefficient, and an enabling
delivery technology is required to direct efficiently these constructs intracellularly. A delivery …

Introduction HIV-1 envelope (Env) is the key target for antibodies (Abs) against the virus and
thus an important HIV-1 vaccine component. Env is synthesized from a gp160 precursor with …

Over the last several years, there has been increased interest from academia and the
pharmaceutical/biotech industry in the development of vaccine adjuvants for new and …

Electroporation (EP) allows for the transport of molecules into the cytoplasm with significant
effectiveness by forming transient pores in the cell membrane using electric pulses. This can …

BACKGROUND RV144 is the only preventive HIV vaccine regimen demonstrating efficacy in
humans. Attempting to build upon RV144 immune responses, we conducted a phase 1 …

Advancement in immunogen selection and vaccine design that will rapidly elicit a protective
Ab response is considered critical for HIV vaccine protective efficacy. Vaccine-elicited Ab …