The emergence and spread of antibiotic resistance is one of the biggest challenges in public
health. There is an urgent need to discover novel agents against the occurrence of multidrug …

Natural polymers have been extensively explored as the vehicles for encapsulation and
delivery of drugs and other bioactive molecules, which have attracted tremendous attention …

Poloxamer 407, also known by the trademark Pluronic® F127, is a water-soluble, non-ionic
triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) …

The wounds closure after physical injury or surgery is of significant clinical and research
importance. In this study, thermosensitive and injectable hydrogels based on hyaluronic acid …

Over the past decades, injectable hydrogels have emerged as promising biomaterials
because of their biocompatibility, excellent permeability, minimal invasion, and easy …

Background. Chemotherapeutic drugs cause severe toxicities if administered unprotected,
without proper targeting, and controlled release. In this study, we developed topotecan‐(TPT …

Introduction: Mucosal drug delivery is an attractive route of administration, particularly in
overcoming deficits of conventional dosage forms including high first-pass metabolism and …

This review focuses on the most recent developments in the field of nanocomposite
hydrogels intended for biomedical applications. Nanocomposite hydrogels are hydrated …

Poloxamer 407 has excellent thermo-sensitive gelling properties. Nevertheless, these gels
possess inadequate poor bioadhesiveness and high permeability to water, which limited its' …

The purpose of this study was to develop novel solid lipid nanoparticle (SLN)-loaded dual-
reverse thermosensitive hydrogel (DRTH) for rectal administration of flurbiprofen with …