Neuroscience in the era of functional genomics and systems biology
DH Geschwind, G Konopka - Nature, 2009 - nature.com
Advances in genetics and genomics have fuelled a revolution in discovery-based, or
hypothesis-generating, research that provides a powerful complement to the more directly …
hypothesis-generating, research that provides a powerful complement to the more directly …
The prognostic landscape of genes and infiltrating immune cells across human cancers
Molecular profiles of tumors and tumor-associated cells hold great promise as biomarkers of
clinical outcomes. However, existing data sets are fragmented and difficult to analyze …
clinical outcomes. However, existing data sets are fragmented and difficult to analyze …
[HTML][HTML] HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers
Summary Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response,
facilitates malignant transformation, cancer cell survival, and proliferation in model systems …
facilitates malignant transformation, cancer cell survival, and proliferation in model systems …
Data standards for Omics data: the basis of data sharing and reuse
To facilitate sharing of Omics data, many groups of scientists have been working to establish
the relevant data standards. The main components of data sharing standards are …
the relevant data standards. The main components of data sharing standards are …
Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy
RM Prins, H Soto, V Konkankit, SK Odesa, A Eskin… - Clinical cancer …, 2011 - AACR
Purpose: To assess the feasibility, safety, and toxicity of autologous tumor lysate–pulsed
dendritic cell (DC) vaccination and toll-like receptor (TLR) agonists in patients with newly …
dendritic cell (DC) vaccination and toll-like receptor (TLR) agonists in patients with newly …
Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways
Because mouse models play a crucial role in biomedical research related to the human
nervous system, understanding the similarities and differences between mouse and human …
nervous system, understanding the similarities and differences between mouse and human …
A global map of human gene expression
M Lukk, M Kapushesky, J Nikkilä, H Parkinson… - Nature …, 2010 - nature.com
Figure 1 Principal component analysis. Each dot represents one of the 5,372 samples in a
multidimensional gene expression space projected on the principal plane formed by the first …
multidimensional gene expression space projected on the principal plane formed by the first …
Gene Expression Commons: an open platform for absolute gene expression profiling
Gene expression profiling using microarrays has been limited to comparisons of gene
expression between small numbers of samples within individual experiments. However, the …
expression between small numbers of samples within individual experiments. However, the …
Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks
Background Age-related macular degeneration (AMD) is a leading cause of blindness that
affects the central region of the retinal pigmented epithelium (RPE), choroid, and neural …
affects the central region of the retinal pigmented epithelium (RPE), choroid, and neural …
Mutations in RSPH1 Cause Primary Ciliary Dyskinesia with a Unique Clinical and Ciliary Phenotype
MR Knowles, LE Ostrowski, MW Leigh… - American journal of …, 2014 - atsjournals.org
Rationale: Primary ciliary dyskinesia (PCD) is a genetically heterogeneous recessive
disorder of motile cilia, but the genetic cause is not defined for all patients with PCD …
disorder of motile cilia, but the genetic cause is not defined for all patients with PCD …