While insomnia is the second most common mental disorder, progress in our understanding
of underlying neurobiological mechanisms has been limited. The present review addresses …

Insomnia disorder (ID) has become the second-most common mental disorder. Despite
burgeoning evidence for increased high-frequency electroencephalography (EEG) activity …

Highlights•Slow waves of NREM sleep can occur locally and asynchronously across brain
regions.•Their regional distribution and amplitude is in part mediated by experience …

Sleep disturbances and depression are closely linked and share a bidirectional relationship.
These interconnections can inform the pathophysiology underlying each condition. Insomnia …

Sleep has been classically described as an all-or-nothing global phenomenon. However,
recent research strongly suggests that this view requires tempering. Invasive and non …

Neuroimaging studies have produced seemingly contradictory findings in regards to the
pathophysiology of insomnia. Although most study results are interpreted from the …

Sleep problems are frequently encountered as presenting complaints in child neurology
clinical practice. They can affect the functioning and quality of life of children, particularly …

What accounts for feeling deeply asleep? Standard sleep recordings only incompletely
reflect subjective aspects of sleep and some individuals with so-called sleep misperception …

Disturbances of the sleep-wake cycle are highly prevalent and diverse. The aetiology of
some sleep disorders, such as circadian rhythm sleep-wake disorders, is understood at the …

Abstract Study Objectives Fast frequency sleep spindles are reduced in aging and
Alzheimer's disease (AD), but the mechanisms and functional relevance of these deficits …