The impact of mitochondrial impairments on sperm function and male fertility: a systematic review

M Vahedi Raad, AM Firouzabadi… - Reproductive Biology …, 2024 - Springer
Background Besides adenine triphosphate (ATP) production for sustaining motility, the
mitochondria of sperm also host other critical cellular functions during germ cell …

Molecular basis for maternal inheritance of human mitochondrial DNA

W Lee, A Zamudio-Ochoa, G Buchel, P Podlesniy… - Nature …, 2023 - nature.com
Uniparental inheritance of mitochondrial DNA (mtDNA) is an evolutionary trait found in
nearly all eukaryotes. In many species, including humans, the sperm mitochondria are …

Evaluation of sperm quality and male fertility: the use of molecular markers in boar sperm and seminal plasma

M Llavanera - Animal Reproduction Science, 2024 - Elsevier
In pig production, the optimization of artificial insemination (AI) efficiency significantly relies
on the accurate assessment of semen quality and fertility of boars. Traditional methods such …

The relationship between sperm nuclear DNA fragmentation, mitochondrial DNA fragmentation, and copy number in normal and abnormal human ejaculates

A Tímermans, F Otero, M Garrido, J Gosálvez… - …, 2024 - Wiley Online Library
Background While it is common to clinically evaluate sperm nuclear DNA fragmentation, less
attention has been given to sperm mitochondrial DNA. Recently, a digital PCR assay has …

Negative correlations of mitochondrial DNA copy number in commercial frozen bull spermatozoa with the motility parameters after thawing

HT Nguyen, SQ Do, H Kobayashi, T Wakai… - Theriogenology, 2023 - Elsevier
The purpose of the current study was to investigate the relationship between mitochondrial
content of commercial frozen-thawed bull spermatozoa and motility. Firstly, mitochondrial …

Sperm function, mitochondrial activity and in vivo fertility are associated to their mitochondrial DNA content in pigs

M Llavanera, Y Mateo-Otero, E Viñolas-Vergés… - Journal of Animal …, 2024 - Springer
Background Despite their low abundance in sperm, mitochondria have diverse functions in
this cell type, including energy production, signalling and calcium regulation. In humans …

Mitochondrial content and mtDNA copy number in spermatozoa and penetrability into oocytes

HT Nguyen, SQ Do, T Wakai, H Funahashi - Theriogenology, 2025 - Elsevier
The current narrative review aims to summarize the relation of mitochondrial content (MC)
and mitochondrial DNA copy number (MDCN) in spermatozoa with sperm penetrability, and …

Association between Sperm Mitochondrial DNA Copy Number and Concentrations of Urinary Cadmium and Selenium

CR Aisyah, Y Mizuno, M Masuda, T Iwamoto… - … Trace Element Research, 2024 - Springer
Elevated sperm mitochondrial DNA copy number (mtDNAcn) is associated with damage to
sperm and poorer measures of semen quality. Exposure to cadmium (Cd) can increase …

Endonuclease G is dispensable for sperm mitochondrial DNA elimination during spermatogenesis in mice

X Xie, J Li, X Zhang, S Mo, A Li, TY Sun… - Biology …, 2024 - journals.biologists.com
Maternal inheritance of mitochondrial DNA (mtDNA) is a widespread phenomenon in
eukaryotes. Our earlier research indicated that sperm mtDNA is removed prior to fertilization …

Increases in computationally predicted deleterious variants of unknown significance and sperm mtDNA copy numbers may be associated with semen quality

Y Pi, Z Huang, X Xu, H Zhang, M Jin, S Zhang… - …, 2024 - Wiley Online Library
Background Mitochondria are essential for sperm motility because they provide the energy
required for the movement. Changes in sperm mtDNA, such as point mutations, large‐scale …