DNA topoisomerase inhibitors are important antineoplastic agents used in the treatment of
both leukemias and solid tumors, such as breast, lung and colon cancers. Their clinical …

Exposure of mammalian cells to X rays results in prolongation of the cell cycle, including
delays or arrests in G1, S and G2 phase. While G1-phase arrest occurs only in cells with wild …

Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in
the presenilin-1 (PS1) gene. PS1 mutations may perturb cellular Ca 2+ homeostasis and …

Cytolethal distending toxin (CDT) from the diarrheagenic bacterium Campylobacter jejuni
was shown to cause a rapid and specific cell cycle arrest in HeLa and Caco-2 cells. Within …

Important aspects of cell cycle regulation are the checkpoints, which respond to a variety of
cellular stresses to inhibit cell cycle progression and act as protective mechanisms to ensure …

Cytolethal distending toxins (CDT) constitute an emerging heterogeneous family of bacterial
toxins whose common biological property is to inhibit the proliferation of cells in culture by …

We have previously found that the overexpression of p53 causes G2 arrest and represses
the synthesis of cyclin-dependent kinase 1 and cyclin B1, two proteins required for cells to …

In this work, we designed a drug delivery nanosystem based on oil-in-water Pluronic F127
nanomicelles to encapsulate and control the release of the antineoplasic drug carfilzomib …

We have studied the effects of phytoestrogens (genistein, quercetin, daidzein, biochanin A
and kaempferol) on proliferation, cell cycle kinetics, and apoptosis of MDA-MB-468 breast …

The induction of tumor cell death by anticancer therapy results from a genetic program of
autonomous cell death termed apoptosis. Because the p53 tumor suppressor gene is a …