Serotonin, 5-hydroxytryptamine (5-HT), is one of the class of monoamine neurontransmitters,
all of which have a chemical template comprised of a basic amino group separated from an …

The neurotransmitter dopamine (DA) has a long association with normal functions such as
motor control, cognition, and reward, as well as a number of syndromes including drug …

Evidence that psychoactive substance use disorders, bulimia nervosa, pathological
gambling, and sexual addiction share an underlying biopsychological process is …

Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …

The role of serotonin in major depressive disorder (MDD) is the focus of accumulating
clinical and preclinical research. The results of these studies reflect the complexity of …

The serotonin (5-HT) 1B receptor is expressed in the central nervous system (CNS) of
rodents and its homologous 5-HT1Dβ receptor is expressed in human. These receptors are …

The interaction of drugs with biologic targets is a critical area of research, particularly for the
development of medications to treat substance use disorders. In addition to understanding …

The evidence for the involvement of the serotonergic system in the pathogenesis of
obsessive-compulsive disorder (OCD) is circumstantial at best, despite being the focus for …

Abstract Serotonin, or 5-hydroxytryptamine (5-HT), is found to be involved in many
physiological or pathophysiological processes including cognitive function. Seven distinct …

Major depressive disorder (MDD) is the leading cause of disability worldwide. The serotonin
hypothesis may be the model of MDD pathophysiology with the most support. The majority of …