Inflammation is a fundamental defensive response to harmful stimuli, but the overactivation
of inflammatory responses is associated with most human diseases. Reactive oxygen …

Significance: Inflammasomes are multiprotein complexes localized within the cytoplasm of
the cell that are responsible for the maturation of proinflammatory cytokines such as …

Inflammation underpins and contributes to the pathogenesis of many retinal degenerative
diseases. The recruitment and activation of both resident microglia and recruited …

Aims: Oxidative stress and neuroinflammation play important roles in the pathology of
Alzheimer's disease (AD). Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor …

Neurological diseases, including acute attacks (eg, ischemic stroke) and chronic
neurodegenerative diseases (eg, Alzheimer's disease), have always been one of the …

Alzheimer's disease (AD) is the most common form of age-associated dementia
characterized by amyloid-ß plaques and neurofibrillary tangles. Recent studies have …

Our previous studies suggested that salidroside could alleviate hepatic steatosis in type 2
diabetic C57BLKS/Leprdb (db/db) mice. The aim of the present study was to evaluate the …

Diabetes pathogenic mechanisms and potential new therapies b... : Current Opinion in
Endocrinology, Diabetes and Obesity Diabetes pathogenic mechanisms and potential new …

Most retinitis pigmentosa (RP) mutations arise in rod photoreceptor genes, leading to
diminished peripheral and nighttime vision. Using a pig model of autosomal-dominant RP …

Redox imbalance in the brain significantly contributes to ischemic stroke pathogenesis, but
antioxidant therapies have failed in clinical trials. Activation of endogenous defense …