Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …

When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-
sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are …

Cellular homeostasis requires the swift and specific removal of damaged material. Selective
autophagy represents a major pathway for the degradation of such cargo material. This is …

Molecular chaperones govern proteome health to support cell homeostasis. An essential
eukaryotic component of the chaperone system is Hsp90. Using a chemical-biology …

To thrive and to fulfill their functions, cells need to maintain proteome homeostasis even in
the face of adverse environmental conditions or radical restructuring of the proteome during …

All cells possess an internal stress response to cope with environmental and
pathophysiological challenges. Upon stress, cells reprogram their molecular functions to …

Sustaining neuronal proteostasis during the course of our life is a central aspect required for
brain function. The dynamic nature of synaptic composition and abundance is a requisite to …

J-domain proteins tune the specificity of Hsp70s, engaging them in precise functions.
Despite their essential role, the structure and function of many J-domain proteins remain …

Protein misfolding is a major driver of ageing‐associated frailty and disease pathology.
Although all cells possess multiple, well‐characterised protein quality control systems to …

Aggregation of the RNA‐binding protein TAR DNA‐binding protein 43 (TDP‐43) is the key
neuropathological feature of neurodegenerative diseases, including amyotrophic lateral …