A rapid increase in the synthesis of lipid-derived second messengers with subsequent
activation of protein phosphorylation cascades has emerged as one of the fundamental …

Diacylglycerol (DAG) and its primary target protein kinase C (PKC) regulate many important
cellular responses, yet the molecular mechanisms that control the specificity of DAG and …

Protein kinase D (PKD) is an evolutionarily conserved protein kinase family with structural,
enzymological, and regulatory properties different from the PKC family members. Signaling …

Hypertrophy of myocytes in the heart ventricles is an important adaptation that in vivo occurs
in response to a requirement for increased contractile power. It involves changes at the level …

Dynamic actin remodelling processes at the leading edge of migrating tumour cells are
concerted events controlled by a fine-tuned temporal and spatial interplay of kinases and …

[Frontiers in Bioscience 3, d1134-1147, November 1, 1998] 1134 SIGNALING THROUGH
PROTEIN KINASE C Alex Toker Signal Transduction Page 1 [Frontiers in Bioscience 3 …

▪ Abstract Gastrin, produced by G cells in the gastric antrum, has been identified as the
circulating hormone responsible for stimulation of acid secretion from the parietal cell …

Autocrine and paracrine signaling leading to stimulation of tumor cell growth is a common
theme in human cancers. In addition to polypeptide growth factors such as EGF family …

Recent research has identified protein kinase D (PKD, also called PKCmu) as a
serine/threonine kinase with potentially important roles in growth factor signaling as well as …

Activation of the serine kinase protein kinase D (PKD)/PKCμ is controlled by the
phosphorylation of two serine residues within its activation loop via a PKC-dependent …