Seven ligands bind to and activate the mammalian epidermal growth factor (EGF) receptor
(EGFR/ERBB1/HER1): EGF, transforming growth factor-alpha (TGFA), heparin-binding EGF …

Heparin-binding epidermal growth factor–like growth factor (HB-EGF) is a member of the
EGF family. It contains an EGF-like domain as well as a heparin-binding domain that allows …

Functional biomaterials that are able to bind, stabilize and release bioactive proteins in a
defined manner are required for the controlled delivery of such to the desired place of action …

Inflammation of the middle ear, known clinically as chronic otitis media, presents in different
forms, such as chronic otitis media with effusion (COME; glue ear) and chronic suppurative …

Chronic tympanic membrane (TM) perforation is a tubotympanic disease caused by either
traumatic injury or inflammation. A recent study demonstrated significant progress in …

Objective To evaluate the efficacy of acellular collagen scaffold (ACS) in combination with
basic fibroblast growth factor (bFGF) for the repair of traumatic tympanic membrane (TM) …

Objective. A systematic review was conducted to compare the effectiveness and safety of
fibroblast growth factor‐2 (FGF2) and epidermal growth factor (EGF) for regeneration of the …

The success rate of grafting using acellular dermal matrix (ADM) for chronic tympanic
membrane was reported in previous studies to be lower than fascia or perichondrium …

Chronic tympanic membrane perforation is a tubotympanic disease caused by traumatic or
inflammatory factors. To date, numerous therapeutic methods have been used to heal …

Research efforts in tympanic membrane regeneration continue to seek the ideal single
tissue-engineered substitute. Recent advances in tympanic membrane bioengineering …