RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the
transcription cycle of protein‐coding genes. This coupling affords opportunities for quality …

Nucleotide excision repair (NER) is a central DNA repair pathway responsible for removing
a wide variety of DNA-distorting lesions from the genome. The highly choreographed …

The clinical efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR-
TKIs) is limited by the emergence of drug resistance. We hypothesise that restoring …

Normal tension glaucoma (NTG) is referred to as a progressive degenerative disorder of the
retinal ganglion cells (RGCs), resulting in nonreversible visual defects, despite intraocular …

Background: Splicing factors are essential for nascent pre-mRNA processing and critical in
cancer progression, suggesting that proteins with splicing functions represent potential …

RNA splicing, transcription and the DNA damage response are intriguingly linked in
mammals but the underlying mechanisms remain poorly understood. Using an in vivo …

Intron retention (IR) is the least well‐understood alternative splicing type in animals, and its
prevalence and function in physiological and pathological processes have long been …

Regulation of alternative splicing (AS) by the splicing factor 3b (SF3B) family plays an
essential role in cancer. However, the biological function of SF3B family members in cervical …

Aging is a critical biological process, with particularly notable impacts on the kidneys.
Exosomes derived from human umbilical cord mesenchymal stem cells (hUC-MSCs) are …

Abstract Eriocalyxin B (EB), 17-hydroxy-jolkinolide B (HJB), parthenolide (PN), xanthatin
(XT) and andrographolide (AG) are terpenoid natural products with a variety of promising …