Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping
Y Kakuta, Y Kinouchi, T Shimosegawa - Journal of Gastroenterology, 2018 - Springer
Abstract The thiopurine drugs 6-mercaptopurine (6-MP) and azathiopurine (AZA) are widely
used to treat inflammatory bowel disease. However, the incidence of adverse reactions is …
used to treat inflammatory bowel disease. However, the incidence of adverse reactions is …
Revisiting the role of thiopurines in inflammatory bowel disease through pharmacogenomics and use of novel methods for therapeutic drug monitoring
SZ Lim, EW Chua - Frontiers in pharmacology, 2018 - frontiersin.org
Azathioprine and 6-mercaptopurine, often referred to as thiopurine compounds, are
commonly used in the management of inflammatory bowel disease. However, patients …
commonly used in the management of inflammatory bowel disease. However, patients …
NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine
Thiopurines are a standard treatment for childhood leukemia, but like all chemotherapeutics,
their use is limited by inherent or acquired resistance in patients. Recently, the nucleoside …
their use is limited by inherent or acquired resistance in patients. Recently, the nucleoside …
Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry
Prolonged exposure to thiopurines (eg, mercaptopurine [MP]) is essential for curative
therapy in acute lymphoblastic leukemia (ALL), but is also associated with frequent dose …
therapy in acute lymphoblastic leukemia (ALL), but is also associated with frequent dose …
Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?
H Zhou, L Li, P Yang, L Yang, JE Zheng, Y Zhou, Y Han - BMC cancer, 2018 - Springer
Abstract Background 6-mercaptopurine (6-MP) contributes substantially to remarkable
improvement in the survival of childhood acute lymphoblastic leukemia (ALL) patients …
improvement in the survival of childhood acute lymphoblastic leukemia (ALL) patients …
Time to incorporate preemptive NUDT15 testing before starting thiopurines in inflammatory bowel disease in Asia and beyond: a review
Introduction Thiopurine toxicity is related to genetic polymorphism. Thiopurine
methyltransferase (TPMT) variants do not explain thiopurine toxicity in more than half of …
methyltransferase (TPMT) variants do not explain thiopurine toxicity in more than half of …
Pathway genes and metabolites in thiopurine therapy in Korean children with acute lymphoblastic leukaemia
Aims We aimed to investigate the impact of various genetic polymorphisms affecting
thiopurine metabolism pathways and toxicity in paediatric acute lymphoblastic leukaemia …
thiopurine metabolism pathways and toxicity in paediatric acute lymphoblastic leukaemia …
The promise of pharmacogenomics in reducing toxicity during acute lymphoblastic leukemia maintenance treatment
S Rudin, M Marable, RS Huang - Genomics, Proteomics and …, 2017 - academic.oup.com
Pediatric acute lymphoblastic leukemia (ALL) affects a substantial number of children every
year and requires a long and rigorous course of chemotherapy treatments in three stages …
year and requires a long and rigorous course of chemotherapy treatments in three stages …
Prevalence of TPMT, ITPA and NUDT 15 genetic polymorphisms and their relation to 6MP toxicity in north Indian children with acute lymphoblastic leukemia
Abstract Purpose Toxicity of 6-Mercaptopurine (6MP) is related to single nucleotide
polymorphism (SNP) in genes coding for metabolizing enzymes, with TPMT analysis being …
polymorphism (SNP) in genes coding for metabolizing enzymes, with TPMT analysis being …
Nucleoside diphosphate‐linked moiety X‐type motif 15 C415T variant as a predictor for thiopurine‐induced toxicity in Indian patients
Abstract Background and Aim Interindividual variation seen in the thiopurine metabolism is
attributed to the genetic variant in thiopurine methyltransferase (TPMT) gene leading to …
attributed to the genetic variant in thiopurine methyltransferase (TPMT) gene leading to …