Current state and future directions in the therapy of ALS

L Tzeplaeff, S Wilfling, MV Requardt, M Herdick - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …

Teleneurology and mobile technologies: the future of neurological care

ER Dorsey, AM Glidden, MR Holloway… - Nature Reviews …, 2018 - nature.com
Neurological disorders are the leading cause of global disability. However, for most people
around the world, current neurological care is poor. In low-income countries, most …

Hypermetabolism in ALS is associated with greater functional decline and shorter survival

FJ Steyn, ZA Ioannides, RPA Van Eijk… - Journal of Neurology …, 2018 - jnnp.bmj.com
Objective To determine the prevalence of hypermetabolism, relative to body composition, in
amyotrophic lateral sclerosis (ALS) and its relationship with clinical features of disease and …

Epidemiology of ALS in Korea using nationwide big data

KY Jun, J Park, KW Oh, EM Kim, JS Bae… - Journal of Neurology …, 2019 - jnnp.bmj.com
Objective This study aimed to determine the incidence, prevalence and survival time of
Korean patients with amyotrophic lateral sclerosis (ALS) using National Health Insurance …

Identification of a circulating miRNA signature in extracellular vesicles collected from amyotrophic lateral sclerosis patients

D Saucier, G Wajnberg, J Roy, AP Beauregard… - Brain Research, 2019 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder associated with the
progressive death of motor neurons. Mean survival for a patient diagnosed with ALS is …

Gene therapy for ALS—a perspective

M Cappella, C Ciotti, M Cohen-Tannoudji… - International journal of …, 2019 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) with no cure.
Recent advances in gene therapy open a new perspective to treat this disorder—particularly …

Evidence‐based consensus guidelines for ALS genetic testing and counseling

J Roggenbuck, BHF Eubank, J Wright… - Annals of Clinical …, 2023 - Wiley Online Library
Objective Advances in amyotrophic lateral sclerosis (ALS) gene discovery, ongoing gene
therapy trials, and patient demand have driven increased use of ALS genetic testing …

Emerging technologies for management of patients with amyotrophic lateral sclerosis: from telehealth to assistive robotics and neural interfaces

R Pugliese, R Sala, S Regondi, B Beltrami… - Journal of Neurology, 2022 - Springer
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …

[HTML][HTML] A road map for remote digital health technology for motor neuron disease

RPA van Eijk, A Beelen, ET Kruitwagen… - Journal of Medical …, 2021 - jmir.org
Despite recent and potent technological advances, the real-world implementation of remote
digital health technology in the care and monitoring of patients with motor neuron disease …

Identification of let-7f and miR-338 as plasma-based biomarkers for sporadic amyotrophic lateral sclerosis using meta-analysis and empirical validation

N Daneshafrooz, MT Joghataei, M Mehdizadeh… - Scientific Reports, 2022 - nature.com
Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease that in most cases
occurs sporadic (sALS). The disease is not curable, and its pathogenesis mechanisms are …