Cytochrome P450 (P450) 21A2 is the major steroid 21-hydroxylase, and deficiency of this
enzyme is involved in∼ 95% of cases of human congenital adrenal hyperplasia, a disorder …

Steroids are an important family of bioactive compounds. Steroid drugs are renowned for
their multifaceted pharmacological activities and are the second-largest category in the …

Cytochrome P450 (P450) reactions can involve C–C bond cleavage, and several of these
are critical in steroid and sterol biosynthesis. The mechanisms of P450s 11A1, 17A1, 19A1 …

Pregna-1, 4, 9 (11), 16 (17)-tetraene-3, 20-dione (pregnatetraenedione) is the most useful
precursor for the synthesis of corticosteroids in industry. However, the production of …

Eleven different laboratory experiments were designed and executed throughout a semester
to provide a meaningful research experience for 23 undergraduate biochemistry majors at …

Human NADPH-cytochrome P450 oxidoreductase (POR) gene mutations are associated
with severe skeletal deformities and disordered steroidogenesis. The human POR mutation …

We investigate the formation, propagation, and interaction of femtosecond laser-induced
flows of compressed air at a water/air interface by recording the transient reflectivity of …

Efficient asymmetric bio-epoxidation of electron-deficient α, β-unsaturated ketones was
realized via a tandem reduction-epoxidation-dehydrogenation cascade, which proceeds in a …

Background Dehydroepiandrosterone sulfate (DHEAS) is the most abundant steroid in
human circulation, and adrenocorticotropic hormone (ACTH) is considered the major …

Abiraterone acetate (AA) is a potent inhibitor of steroidogenic enzyme 17 α-hydroxylase/17,
20-lyase (CYP17A1). AA is approved for the treatment of prostate cancer but could also be …