Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Head and neck cancer is a group of neoplastic diseases affecting the facial, oral, and neck
region. It is one of the most common cancers worldwide with an aggressive, invasive …

Esophageal cancer has a strikingly low survival rate mainly due to the lack of diagnostic
markers for early detection and effective therapies. In the US, 75% of individuals diagnosed …

Genomics studies have detected numerous genetic alterations in esophageal squamous
cell carcinoma (ESCC). However, the functions of these mutations largely remain elusive …

The genomic landscape of esophageal squamous cell cancer (ESCC), as well as its impact
on the regulation of immune microenvironment, is not well understood. Thus, tumor samples …

The objective was to gain proof of genome damage-repair induced mitotic slippage process
(MSP) to 4n-diplochromosome skewed division-system, earlier suggested to have “cancer …

In a series of publications, the hypothesis of a special-type of endo-polyploidy, marked by 4-
chromatid chromosomes (diplochromosomes), in the initiation of tumorigenesis has been …

Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EA) are
the two main subtypes of esophageal cancer. Genetics underpinnings of EA are …

Single-cell sequencing technologies have unsurprisingly become a favourable choice for
studying key biological questions about cell heterogeneity, rare cell types or lineages. It is …

In a series of publications a special, tetraploid diplochromosomal division system to only two
types of progeny cells (4n/4C/G1 and 2n/4C para-diploid) has been suggested to initiate …