Invariant natural killer T cells: bridging innate and adaptive immunity

L Van Kaer, VV Parekh, L Wu - Cell and tissue research, 2011 - Springer
Cells of the innate immune system interact with pathogens via conserved pattern-recognition
receptors, whereas cells of the adaptive immune system recognize pathogens through …

Natural killer T cells and autoimmune disease

L Wu, LV Kaer - Current molecular medicine, 2009 - ingentaconnect.com
Natural killer T (NKT) cells are an unusual subset of innate immune cells that express a
surface receptor generated by somatic DNA rearrangement, a hallmark of cells of the …

[HTML][HTML] Natural killer T cells in health and disease

L Wu, L Van Kaer - Frontiers in bioscience (Scholar edition), 2011 - ncbi.nlm.nih.gov
Natural killer T (NKT) cells are a subset of T lymphocytes that share surface markers and
functional characteristics with both conventional T lymphocytes and natural killer cells. Most …

Mechanism of regulation of autoimmunity by iNKT cells

J Novak, A Lehuen - Cytokine, 2011 - Elsevier
iNKT cells, CD1d dependent natural killer T cells are a unique population of T cells. The
capacity of iNKT cells to produce regulatory cytokines first provided an indication of their …

Dendritic cells and aging: consequences for autoimmunity

A Agrawal, A Sridharan, S Prakash… - Expert review of clinical …, 2012 - Taylor & Francis
The immune system has evolved to mount immune responses against foreign pathogens
and to remain silent against self-antigens. A balance between immunity and tolerance is …

Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection

D Di Liberto, M Locati, N Caccamo, A Vecchi… - The Journal of …, 2008 - rupress.org
D6 is a decoy and scavenger receptor for inflammatory CC chemokines. D6-deficient mice
were rapidly killed by intranasal administration of low doses of Mycobacterium tuberculosis …

Invariant NKT cells limit activation of autoreactive CD1d-positive B cells

F Wermeling, SM Lind, ED Jordö, SL Cardell… - Journal of Experimental …, 2010 - rupress.org
Faulty activation of autoreactive B cells is a hallmark of autoimmune diseases like systemic
lupus erythematosus (SLE). An important feature restricting activation of autoreactive B cells …

Invariant natural killer T cells: innate‐like T cells with potent immunomodulatory activities

L Wu, CL Gabriel, VV Parekh, L Van Kaer - Tissue antigens, 2009 - Wiley Online Library
Invariant natural killer T (iNKT) cells are a subset of T lymphocytes that react with glycolipid
antigens presented by the major histocompatibility complex class I‐related glycoprotein …

Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3β loop

G Matulis, JP Sanderson, NM Lissin… - PLoS …, 2010 - journals.plos.org
Invariant Natural Killer T cells (iNKT) are a versatile lymphocyte subset with important roles
in both host defense and immunological tolerance. They express a highly conserved TCR …

Immunoregulation of NKT cells in systemic lupus erythematosus

J Chen, M Wu, J Wang, X Li - Journal of immunology research, 2015 - Wiley Online Library
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with different
variety of clinical manifestations. Natural killer T (NKT) cells are innate lymphocytes that play …