Autism spectrum disorder: a review

T Hirota, BH King - Jama, 2023 - jamanetwork.com
Importance Autism spectrum disorder (ASD), characterized by deficits in social
communication and the presence of restricted, repetitive behaviors or interests, is a …

[HTML][HTML] An update on psychopharmacological treatment of autism spectrum disorder

R Aishworiya, T Valica, R Hagerman, B Restrepo - Neurotherapeutics, 2022 - Elsevier
While behavioral interventions remain the mainstay of treatment of autism spectrum disorder
(ASD), several potential targeted treatments addressing the underlying neurophysiology of …

Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Oxytocin receptor is not required for social attachment in prairie voles

KM Berendzen, R Sharma, MA Mandujano, Y Wei… - Neuron, 2023 - cell.com
Prairie voles are among a small group of mammals that display long-term social attachment
between mating partners. Many pharmacological studies show that signaling via the …

Evaluation of recent intranasal drug delivery systems to the central nervous system

TP Crowe, WH Hsu - Pharmaceutics, 2022 - mdpi.com
Neurological diseases continue to increase in prevalence worldwide. Combined with the
lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a …

Pharmacological and dietary-supplement treatments for autism spectrum disorder: a systematic review and network meta-analysis

S Siafis, O Çıray, H Wu, J Schneider-Thoma, I Bighelli… - Molecular autism, 2022 - Springer
Background There is still no approved medication for the core symptoms of autism spectrum
disorder (ASD). This network meta-analysis investigated pharmacological and dietary …

The effect of oxytocin nasal spray on social interaction in young children with autism: a randomized clinical trial

AJ Guastella, KA Boulton, AJO Whitehouse… - Molecular …, 2023 - nature.com
Early supports to enhance social development in children with autism are widely promoted.
While oxytocin has a crucial role in mammalian social development, its potential role as a …

Infrequent intranasal oxytocin followed by positive social interaction improves symptoms in autistic children: a pilot randomized clinical trial

J Le, L Zhang, W Zhao, S Zhu, C Lan, J Kou… - Psychotherapy and …, 2022 - karger.com
Introduction: There are currently no approved drug interventions for social behavior
dysfunction in autism spectrum disorder (ASD). Previous trials investigating effects of daily …

Refining oxytocin therapy for autism: context is key

CL Ford, LJ Young - Nature Reviews Neurology, 2022 - nature.com
A recent clinical trial found no effect of chronic intranasal oxytocin on social behaviour in
children with autism spectrum disorders. The result is not surprising, as oxytocin facilitates …

Oxytocin—a social peptide? Deconstructing the evidence

G Leng, RI Leng, M Ludwig - … Transactions of the …, 2022 - royalsocietypublishing.org
In this paper, we analyse the claim that oxytocin is a 'social neuropeptide'. This claim
originated from evidence that oxytocin was instrumental in the initiation of maternal …