Brain metastases are a very common manifestation of cancer that have historically been
approached as a single disease entity given the uniform association with poor clinical …

An estimated 20% of all patients with cancer will develop brain metastases, with the majority
of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma …

Metastatic tumours involving the brain overshadow primary brain neoplasms in frequency
and are an important complication in the overall management of many cancers. Importantly …

Non-small cell lung cancer (NSCLC) harboring an activating epidermal growth factor
receptor (EGFR) mutation shows good and rapid response to EGFR tyrosine kinase …

Bone and brain metastases are a very common secondary localization of disease in patients
with lung cancer. The prognosis of these patients is still poor with a median survival of less …

Learning Objectives After completing this course, the reader will be able to: Identify the
clinical factors that predict survival after a diagnosis of brain metastasis. Select appropriate …

Brain metastases are an important sequelae of many types of cancer, most commonly lung
cancer. Current treatment options include whole-brain radiation therapy (WBRT), surgical …

Cisplatin continues to play a central role in cancer chemotherapy in spite of its toxicity. It is
used as first-line chemotherapy against epithelial malignancies of lung, ovarian, bladder …

There is no accepted standard of care for the chemotherapy treatment of metastatic brain
tumors, which has been generally limited to lipophilic alkylators, which may not have efficacy …

Brain metastases (BrMs) are associated with significant morbidity and are found in up to
50% of patients with advanced non-small cell lung cancer (NSCLC). Most of the literature …