The NFAT family of transcription factors encompasses five proteins evolutionarily related to
the Rel/NFκB family (Chytil and Verdine 1996; Graef et al. 2001b). The primordial family …

▪ Abstract As targets for the immunosuppressive drugs cyclosporin A and FK506,
transcription factors of the NFAT (nuclear factor of activated T cells) family have been the …

In response to numerous pathologic stimuli, the myocardium undergoes a hypertrophic
response characterized by increased myocardial cell size and activation of fetal cardiac …

Nuclear factor of activated T cells (NFAT) was first identified more than two decades ago as
a major stimulation-responsive DNA-binding factor and transcriptional regulator in T cells. It …

Glycogen synthase kinase-3β (GSK3β) is a fascinating enzyme with an astoundingly diverse
number of actions in intracellular signaling systems. GSK3β activity is regulated by serine …

Combinatorial regulation is a powerful mechanism that enables tight control of gene
expression, via integration of multiple signaling pathways that induce different transcription …

Nuclear factor of activated T cells (NFAT) was first described almost three decades ago as a
Ca 2+/calcineurin-regulated transcription factor in T cells. Since then, a large body of …

Fos and Jun family proteins regulate the expression of a myriad of genes in a variety of
tissues and cell types. This functional versatility emerges from their interactions with related …

Calcineurin is a calcium activated protein phosphatase with a major role in calcium
signaling in diverse cells and organs and clinical importance as the target of the …

Undifferentiated small round cell sarcomas (SRCSs) of bone and soft tissue comprise a
heterogeneous group of highly aggressive tumours associated with a poor prognosis …