Unfolding the cascade of SERPINA3: Inflammation to cancer

A Soman, SA Nair - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Abstract SERine Protease INhibitor clade A member 3 (SERPINA3), a member of the
SERine-Protease INhibitor (SERPIN) superfamily, principally works as a protease inhibitor in …

Obesity and gastrointestinal cancer: the interrelationship of adipose and tumour microenvironments

J O'Sullivan, J Lysaght, CL Donohoe… - Nature reviews …, 2018 - nature.com
Increasing recognition of an association between obesity and many cancer types exists, but
how the myriad of local and systemic effects of obesity affect key cellular and non-cellular …

Modulating iron for metabolic support of TB host defense

JJ Phelan, SA Basdeo, SC Tazoll, S McGivern… - Frontiers in …, 2018 - frontiersin.org
Tuberculosis (TB) is the world's biggest infectious disease killer. The increasing prevalence
of multidrug-resistant and extensively drug-resistant TB demonstrates that current treatments …

Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib

AM Buckley, MR Dunne, ME Morrissey, SA Kennedy… - Scientific reports, 2020 - nature.com
Oesophageal cancer is the 6th most common cause of cancer related death worldwide. The
current standard of care for oesophageal adenocarcinoma (OAC) focuses on neoadjuvant …

Preclinical Organotypic Models for the Assessment of Novel Cancer Therapeutics and Treatment

C Ward, J Meehan, M Gray, IH Kunkler… - … Organotypic Models for …, 2021 - Springer
The immense costs in both financial terms and preclinical research effort that occur in the
development of anticancer drugs are unfortunately not matched by a substantial increase in …

[PDF][PDF] A pathways-based approach identifying determinants of drug resistance in oesophageal adenocarcinoma

N McCabe - 2021 - pure.qub.ac.uk
The aim of this chapter was to carry out gene set enrichment analysis on the resulting data
from pre-treatment OAC biopsies, transcriptionally profiled by the Almac Xcel Array. The goal …

[引用][C] Exploring the influence of obesity, fatty acids, and current treatment modalities on the immune-metabolic profiles of adipose tissue in oesophageal cancer.

F O'Connell - 2023 - School of Biological Sciences …