The sensitivity of magnetic resonance imaging to biochemical and biophysical changes in
the extracellular matrix of articular cartilage give it the potential to noninvasively detect the …

Osteoarthritis (OA) has become the most prevalent chronic disease of the elderly (1, 2) and
is an important cause of disability in our society with increasing incidence not only in the US …

OBJECTIVE: Evaluation and treatment of patients with early stages of osteoarthritis (OA) is
dependent upon an accurate assessment of the cartilage lesions. However, standard …

It has been suggested that orientational changes in the collagen network of articular
cartilage account for the depthwise T2 anisotropy of MRI through the magic angle effect. To …

Purpose To quantify the spin‐lattice relaxation time in the rotating frame (T1ρ) in various
clinical grades of human osteoarthritis (OA) cartilage specimens obtained from total knee …

Objective The aim of this study was to investigate, using T2-mapping, the impact of
functional instability in the ankle joint on the development of early cartilage damage …

T2 and T1ρ have potential to nondestructively detect cartilage degeneration. However,
reports in the literature regarding their diagnostic interpretation are conflicting. In this study …

Degradation of collagen network and proteoglycan (PG) macromolecules are signs of
articular cartilage degeneration. These changes impair cartilage mechanical function …

Abstract Structure and properties of knee articular cartilage are adapted to stresses exposed
on it during physiological activities. In this study, we describe site‐and depth‐dependence of …

RATIONALE AND OBJECTIVES: The authors performed this study to (a) measure changes
in T2 relaxation rates, signal-to-noise ratio (SNR), and contrast with sequential depletion of …