A major challenge in Parkinson's disease is the variability in symptoms and rates of
progression, underpinned by heterogeneity of pathological processes. Biomarkers are …

Research in ultrahigh magnetic field strength combined with ultrahigh and ultrafast gradient
technology has provided enormous gains in sensitivity, resolution, and contrast for …

Recently, mesenchymal stromal cell (MSC)-based therapy has become an appreciated
therapeutic approach in the context of neurodegenerative disease therapy. Accordingly, a …

Purpose This study aimed to develop and validate a radiomics model based on whole‐brain
white matter and clinical features to predict the progression of Parkinson disease (PD) …

Parkinson's disease (PD) is a prevalent neurodegenerative disorder that presents a
diagnostic challenge due to symptom overlap with other disorders. Neuromelanin (NM) …

Rigidity is one of the common motor disorders in Parkinson's disease (PD), which lead to life
quality deterioration. The widely-used rating-scale-based approach for rigidity assessment …

Neurodegenerative disorders are a diversity of disorders, surrounding Alzheimer's (AD),
Parkinson's (PD), Huntington's diseases (HD), and amyotrophic lateral sclerosis (ALS) …

Alzheimer's disease (AD) is the leading cause of dementia due to neurodegeneration and is
characterized by extracellular senile plaques composed of amyloid β1–42 (Aβ) as well as …

Background Freezing of gait (FOG) is a common symptom in Parkinson's Disease (PD)
patients. Previous studies have reported relationships between FOG, substantia nigra (SN) …

Objective Bradykinesia and rigidity are considered closely related motor signs in Parkinson
disease (PD), but recent neurophysiological findings suggest distinct pathophysiological …